Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …

Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …

Melanoma is the deadliest type of skin cancer. Human melanomas often show hyperactivity
of nitric oxide synthase (NOS) and NADPH oxidase (NOX), which, respectively, generate …

Melanoma is the most aggressive skin cancer, with a growing number of incidents
worldwide and with no effective cure in a metastatic stage so far. There are several …

Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …

Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to
its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its …

Melanoma is an extremely aggressive form of skin cancer that can spread to the lungs,
brain, and liver, among other vital organs. Melanoma cells, unlike any other cancer cells …

Cutaneous malignant melanoma is rapidly increasing in the developed world and continues
to be a challenge in the clinic. Although extensive epidemiologic evidence points to solar UV …

Low melanin level in white skin results in many genetic alterations that activate oncogenes
to form metastatic melanomas because of interaction with ultraviolet rays. These melanomas …