OBJECTIVE: Longitudinal studies employing intravital imaging techniques carry potential to
improve understanding of peripheral nerve regeneration and function. Using multiphoton …

This protocol describes consistent and reproducible methods to study axonal regeneration
and inhibition in a rat facial nerve injury model. The facial nerve can be manipulated along …

MRI (magnetic resonance imaging) is an indispensable tool in the diagnosis of centrals
nervous system (CNS) disorders such as spinal cord injury and multiple sclerosis (MS). In …

Importance Facial nerve injury leads to severe functional and aesthetic deficits. The
transgenicThy1-GFPrat is a new model for facial nerve injury and reconstruction research …

Despite advances in microsurgical technology and an improved understanding of nerve
regeneration, obtaining satisfactory results after facial nerve injury remains a difficult clinical …

Objective To introduce a Thy1-GFP transgenic rat model, whose axons constitutively
express green fluorescent protein (GFP), in order to study facial nerve regeneration. Facial …

Surgical intervention followed by physical therapy remains the major way to repair damaged
nerves and restore function. Imaging constitutes promising, yet underutilized, approaches to …

Objective: The mainstays of peripheral nerve research have historically involved quantifying
nerve regeneration by the staining of fixed specimens at multiple time points and by …

Extremity injuries are less likely to be fatal than head, chest, and abdominal wounds;
however, they can be severely disabling. Peripheral nerve injury (PNI) can result from …

Objective Delayed peripheral nerve repair is complicated by nerve degeneration and
atrophy that can prevent identification. We use a murine facial nerve transection model to …