[HTML][HTML] CXCR4-targeted theranostics in oncology
A growing body of literature reports on the upregulation of CXC motif chemokine receptor 4
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …
[HTML][HTML] CXCR4-directed theranostics in oncology and inflammation
Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …
[HTML][HTML] Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging
Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor …
High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist
CXC chemokine receptor 4 (CXCR4) is highly expressed in cancers, contributing to
proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can …
proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can …
PET of CXCR4 expression by a 68Ga-labeled highly specific targeted contrast agent
E Gourni, O Demmer, M Schottelius… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The overexpression of the chemokine receptor CXCR4 plays an important role in oncology,
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
since together with its endogenous ligand, the stromal cell–derived factor (SDF1-α), CXCR4 …
Chemokine receptor–directed imaging and therapy
AK Buck, A Stolzenburg, H Hänscheid, A Schirbel… - Methods, 2017 - Elsevier
The CXC chemokine receptor 4 (CXCR4) and its natural ligand CXCL12 are key factors in
the process of cell migration, homing of hematopoietic stem cells to the bone marrow, and …
the process of cell migration, homing of hematopoietic stem cells to the bone marrow, and …
CXCR4-based imaging agents
LE Woodard, S Nimmagadda - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
Chemokine receptor 4 (CXCR4)–chemokine ligand 12 (CXCL12) interactions have been
shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion …
shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion …
Improvement of CXCR4 tracer specificity for PET imaging
O Jacobson, ID Weiss, LP Szajek, G Niu, Y Ma… - Journal of controlled …, 2012 - Elsevier
Tumors expressing the chemokine receptor CXCR4 have been reported to be more
aggressive and to produce more metastatic seeding in specific organs, such as the bone …
aggressive and to produce more metastatic seeding in specific organs, such as the bone …
CXCR4 ligands: the next big hit?
AME Walenkamp, C Lapa, K Herrmann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The G protein–coupled protein receptor CXC chemokine receptor 4 (CXCR4) is an attractive
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …
target for cancer diagnosis and treatment, as it is overexpressed in many solid and …
Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465
RA De Silva, K Peyre, M Pullambhatla… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The chemokine receptor 4 (CXCR4) is overexpressed in several cancers and metastases
and as such presents an enticing target for molecular imaging of metastases and metastatic …
and as such presents an enticing target for molecular imaging of metastases and metastatic …