Microbial functional responses to cholesterol catabolism in denitrifying sludge

STS Wei, YW Wu, TH Lee, YS Huang, CY Yang… - Msystems, 2018 - Am Soc Microbiol
ABSTRACT The 2, 3-seco pathway, the pathway for anaerobic cholesterol degradation, has
been established in the denitrifying betaproteobacterium Sterolibacterium denitrificans …

Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans

CW Lin, PH Wang, W Ismail, YW Tsai, A El Nayal… - Journal of Biological …, 2015 - ASBMB
Cholesterol catabolism by actinobacteria has been extensively studied. In contrast, the
uptake and catabolism of cholesterol by Gram-negative species are poorly understood …

A patchwork pathway for oxygenase‐independent degradation of side chain containing steroids

M Warnke, C Jacoby, T Jung, M Agne… - Environmental …, 2017 - Wiley Online Library
The denitrifying betaproteobacterium Sterolibacterium denitrificans serves as model
organism for studying the oxygen‐independent degradation of cholesterol. Here, we …

Functional characterization of three specific acyl-coenzyme A synthetases involved in anaerobic cholesterol degradation in Sterolibacterium denitrificans Chol1S

M Warnke, T Jung, C Jacoby, M Agne… - Applied and …, 2018 - Am Soc Microbiol
The denitrifying betaproteobacterium Sterolibacterium denitrificans Chol1S catabolizes
steroids such as cholesterol via an oxygen-independent pathway. It involves enzyme …

Mycobacterial species and their contribution to cholesterol degradation in wastewater treatment plants

F Guo, T Zhang, B Li, Z Wang, F Ju, Y Liang - Scientific reports, 2019 - nature.com
Mycobacterium often presents as an abundant bacterial genus in activated sludge in many
wastewater treatment plants (WWTPs), but the species-level taxonomy and functions remain …

Anaerobic biodegradation of steroids

YR Chiang, W Ismail - Anaerobic utilization of hydrocarbons, oils, and …, 2020 - Springer
Steroids, comprising sterols, steroid hormones, and bile acids, are ubiquitous and abundant
in nature. Steroids are largely produced by eukaryotes; however, their complete degradation …

An oxygenase-independent cholesterol catabolic pathway operates under oxic conditions

PH Wang, TH Lee, W Ismail, CY Tsai, CW Lin… - PLoS …, 2013 - journals.plos.org
Cholesterol is one of the most ubiquitous compounds in nature. The 9, 10-seco-pathway for
the aerobic degradation of cholesterol was established thirty years ago. This pathway is …

De novo cholesterol biosynthesis in the bacterial domain

AK Lee, JH Wei, PV Welander - bioRxiv, 2022 - biorxiv.org
Sterols are versatile lipids primarily associated with eukaryotes. While bacteria also produce
sterols and studies of bacterial biosynthesis proteins have revealed novel biosynthetic …

Genome-Wide Transcriptome Profiling Provides Insight on Cholesterol and Lithocholate Degradation Mechanisms in Nocardioides simplex VKM Ac-2033D

VY Shtratnikova, MI Schelkunov, VV Fokina, EY Bragin… - Genes, 2020 - mdpi.com
Steroid microbial degradation plays a significant ecological role for biomass decomposition
and removal/detoxification of steroid pollutants. In this study, the initial steps of cholesterol …

Characterization of interactions of dietary cholesterol with the murine and human gut microbiome

HH Le, MT Lee, KR Besler, JMC Comrie… - Nature …, 2022 - nature.com
Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with
consequences for host health through the production of microbiome-derived metabolites …