Coupling hot-melt extrusion (HME) with fused deposition modeling three-dimensional
printing (FDM-3DP) can facilitate the fabrication of tailored, patient-centered, and complex …

This study developed, optimized, characterized, and evaluated bioadhesive, hot-melt
extruded (HME), extended-release ocular inserts containing ciprofloxacin hydrochloride …

Conventional anti-infective eye drops are the most common forms of drugs prescribed for the
management of topical ocular infections. Despite their convenience, topical eye drops face …

Abstract 3D printing technology is a novel and practical approach for producing unique and
complex industrial and medical objects. In the pharmaceutical field, the approval of 3D …

Purpose: Soluble ocular inserts of ciprofloxacin hydrochloride were prepared with the aim of
achieving once a day administration. Design: Drug reservoir was prepared using natural …

Ciprofloxacin (Cf) is antibiotic used oculary for treatment of conjunctivitis and corneal ulcers.
The barriers for its use are: high dosage frequency and poor solubility lead to ocular …

The objective of the present study was to design controlled release ophthalmic delivery
systems for ciprofloxacin based on polymeric carriers that undergo sol-to-gel transition upon …

Conventional eye drops are most commonly employed topically in the eye for the
management of bacterial conjunctivitis. Eye drops have a low corneal residence time and 90 …

Purpose: An attempt has been made in the present research to formulate soluble ocular
inserts of ciprofloxacin hydrochloride to increase residence time and prolong drug release …

Reservoir-type ocular inserts were fabricated using sodium alginate containing ciprofloxacin
hydrochloride as the core (drug reservoir) that was sandwiched between the Eudragit and/or …