Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious
inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women …

Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has
been investigated as a potential mechanism for the differences in pain modulation observed …

Old age and female sex are risk factors for the development of osteoarthritis (OA) and
chronic pain. We investigated the effects of sex and age on pain modulatory networks in a …

Growing evidence suggests that aging is associated with impaired endogenous pain
modulation, and that this likely underlies the increased transition from acute to chronic pain …

Aging populations are more sensitive to noxious stimuli as a result of altered somatosensory
systems. In these experiments, we examined pain-like behaviors in young, middle-aged …

The processing of pain undergoes several changes in aging that affect sensory nociceptive
fibers and the endogenous neuronal inhibitory systems. So far, it is not completely clear …

Aging affects pain experience and brain functioning. However, how aging leads to changes
in pain perception and brain functional connectivity has not yet been completely understood …

Altered function of endogenous pain modulation has been proposed as a mechanism that
may underlie chronic pain conditions. Descending modulation of pain can be examined by …

Objective. Preclinical studies of pain and aging represent an area of research where
considerations of age, strain, gender, and method of behavioral assessment are but some of …

Alterations in the affective component of pain perception are related to the development of
chronic pain and may contribute to the increased vulnerability to pain observed in aging …