Brain networks and endogenous pain inhibition are modulated by age and sex in healthy rats
JT Da Silva, C Tricou, Y Zhang, DA Seminowicz, JY Ro - Pain, 2020 - journals.lww.com
Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious
inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women …
inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women …
[HTML][HTML] Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats
JT Da Silva, Y Zhang, J Asgar, JY Ro… - Behavioural brain …, 2018 - Elsevier
Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has
been investigated as a potential mechanism for the differences in pain modulation observed …
been investigated as a potential mechanism for the differences in pain modulation observed …
Pain modulatory network is influenced by sex and age in a healthy state and during osteoarthritis progression in rats
JT Da Silva, C Tricou, Y Zhang, A Tofighbakhsh… - Aging …, 2021 - Wiley Online Library
Old age and female sex are risk factors for the development of osteoarthritis (OA) and
chronic pain. We investigated the effects of sex and age on pain modulatory networks in a …
chronic pain. We investigated the effects of sex and age on pain modulatory networks in a …
[HTML][HTML] Age-related differences in functional connectivity associated with pain modulation
M van der Meulen, KM Rischer, AMG Roldán… - Neurobiology of …, 2024 - Elsevier
Growing evidence suggests that aging is associated with impaired endogenous pain
modulation, and that this likely underlies the increased transition from acute to chronic pain …
modulation, and that this likely underlies the increased transition from acute to chronic pain …
Central amygdala activation of extracellular signal-regulated kinase 1 and age-dependent changes in inflammatory pain sensitivity in mice
Aging populations are more sensitive to noxious stimuli as a result of altered somatosensory
systems. In these experiments, we examined pain-like behaviors in young, middle-aged …
systems. In these experiments, we examined pain-like behaviors in young, middle-aged …
Age-dependent changes in the inflammatory nociceptive behavior of mice
TS King-Himmelreich, CV Möser, MC Wolters… - International journal of …, 2015 - mdpi.com
The processing of pain undergoes several changes in aging that affect sensory nociceptive
fibers and the endogenous neuronal inhibitory systems. So far, it is not completely clear …
fibers and the endogenous neuronal inhibitory systems. So far, it is not completely clear …
Age-related changes in pain perception are associated with altered functional connectivity during resting state
AM González-Roldán, JL Terrasa, C Sitges… - Frontiers in Aging …, 2020 - frontiersin.org
Aging affects pain experience and brain functioning. However, how aging leads to changes
in pain perception and brain functional connectivity has not yet been completely understood …
in pain perception and brain functional connectivity has not yet been completely understood …
[HTML][HTML] Perspective on diffuse noxious inhibitory controls as a model of endogenous pain modulation in clinical pain syndromes
G van Wijk, DS Veldhuijzen - The Journal of Pain, 2010 - Elsevier
Altered function of endogenous pain modulation has been proposed as a mechanism that
may underlie chronic pain conditions. Descending modulation of pain can be examined by …
may underlie chronic pain conditions. Descending modulation of pain can be examined by …
The effects of age on pain sensitivity: preclinical studies
RP Yezierski - Pain medicine, 2012 - academic.oup.com
Objective. Preclinical studies of pain and aging represent an area of research where
considerations of age, strain, gender, and method of behavioral assessment are but some of …
considerations of age, strain, gender, and method of behavioral assessment are but some of …
Anterior cingulate cortex activity during rest is related to alterations in pain perception in aging
Alterations in the affective component of pain perception are related to the development of
chronic pain and may contribute to the increased vulnerability to pain observed in aging …
chronic pain and may contribute to the increased vulnerability to pain observed in aging …