How I diagnose and treat atypical hemolytic uremic syndrome

F Fakhouri, N Schwotzer… - Blood, The Journal of …, 2023 - ashpublications.org
Our understanding and management of atypical hemolytic uremic syndrome (aHUS) have
dramatically improved in the last decade. aHUS has been established as a prototypic …

Atypical hemolytic uremic syndrome: a brief review

K Zhang, Y Lu, KT Harley, MH Tran - Hematology reports, 2017 - mdpi.com
Atypical hemolytic uremic syndrome (aHUS) is a disease characterized by the triad of
microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. The …

Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy

F Fakhouri, V Frémeaux-Bacchi, C Loirat - European Journal of Internal …, 2013 - Elsevier
Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic
microangiopathy. In the last five years, we have finally witnessed a dramatic improvement in …

Current treatment of atypical hemolytic uremic syndrome

BS Kaplan, RL Ruebner, JM Spinale… - Intractable & rare …, 2014 - jstage.jst.go.jp
Tremendous advances have been made in understanding the pathogenesis of atypical
Hemolytic Uremic Syndrome (aHUS), an extremely rare disease. Insights into the molecular …

Atypical Hemolytic–Uremic Syndrome: A Clinical Review

A Nayer, A Asif - American journal of therapeutics, 2016 - journals.lww.com
Atypical hemolytic–uremic syndrome (HUS) is a rare life-threatening disorder characterized
by microangiopathic hemolytic anemia, thrombocytopenia, and ischemic injury to organs …

Clinical grand rounds: atypical hemolytic uremic syndrome

KS Hodgkins, AE Bobrowski, JC Lane… - American Journal of …, 2012 - karger.com
Atypical hemolytic uremic syndrome (aHUS) is a rare, lifethreatening, chronic, genetic
disease of uncontrolled alternative pathway complement activation. The understanding of …

Atypical hemolytic uremic syndrome, genetic basis, and clinical manifestations

D Kavanagh, THJ Goodship - Hematology 2010, the American …, 2011 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is now well recognized to be a disease
characterized by excessive complement activation in the microvasculature. In both the …

Complement‐driven hemolytic uremic syndrome

J Leon, MB LeStang, R Sberro‐Soussan… - American Journal of …, 2023 - Wiley Online Library
Overactivation of the complement alternative pathway drives the pathogenesis of primary
atypical hemolytic uremic syndrome (aHUS). Genetically‐determined or acquired …

Atypical hemolytic uremic syndrome: update on the complement system and what is new

P Hirt-Minkowski, M Dickenmann… - Nephron Clinical Practice, 2010 - karger.com
Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic
anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the …

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

LT Roumenina, M Frimat, EC Miller… - Blood, The Journal …, 2012 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a rare renal thrombotic microangiopathy
commonly associated with rare genetic variants in complement system genes, unique to …