In many neurologic disorders, injury to neurons may be caused at least in part by
overstimulation of receptors for excitatory amino acids, including glutamate and aspartate …

This review describes recent advances in our understanding of the pharmacology of
excitatory amino acid receptors, and the application of this knowledge to the unravelling of …

Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous
system (CNS). Specific receptors bind glutamate and some of these when activated open an …

Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …

PURPOSE: To review the role of excitatory neurotransmitters in normal mammalian brain
function, the concept of excitotoxic neuronal death as an important final common path in a …

The excitatory potency of the acidic amino acids glutamate and aspartate in various regions
of the central nervous system (CNS) has been recognized since the 1960 s. 1, 2 …

Excessive excitation by neurotransmitters can cause the death of neurons. This excitotoxic
action may be responsible for neuronal loss in stroke, cerebral palsy, epilepsy, ageing and …

Publisher Summary Glutamate is involved in various physiological neuronal processes
including execution of motor acts, nociception, learning, and memory. A substantial body of …

Background Recent evidence suggests an altered glutamate homeostasis in the brain of
patients with multiple sclerosis (MS), as seen in experimental models of MS. Objective To …

The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in
many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids …