The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia
as their common denominator. In this review, we describe the biochemical and histological …

Here, we describe the generation and characterization of a novel tau transgenic mouse
model (mTau) that overexpresses wild-type murine tau protein by twofold compared with …

Tau protein is the major component of the intracellular filamentous deposits that define a
number of neurodegenerative diseases. They include the largely sporadic Alzheimer's …

Our aims are to review animal models of tauopathies, which include a number of brain
disorders with various aetiologies, including ageing, genetics, infectious diseases, toxins …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Tau becomes characteristically altered both functionally and structurally in several
neurodegenerative diseases now collectively called tauopathies. Although increasing …

Tauopathies are age-related neurodegenerative diseases that are characterized by the
presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered …

Both Alzheimer′ s disease (AD) and frontotemporal dementia (FTD) are characterized by
the deposition of hyperphosphorylated forms of the microtubule‐associated protein tau in …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …