Estimating the lowest detectable dose of ionizing radiation by the cytokinesis-block micronucleus assay

JD Tucker, M Vadapalli, MC Joiner… - Radiation …, 2013 - meridian.allenpress.com
The frequency of binucleated cells containing one or more micronuclei (MNBN cells) in
cytokinesis-blocked peripheral blood lymphocytes can be used to determine whether a …

Development of a high-throughput and miniaturized cytokinesis-block micronucleus assay for use as a biological dosimetry population triage tool

SW Lue, M Repin, R Mahnke… - Radiation …, 2015 - meridian.allenpress.com
Biodosimetry is an essential tool for providing timely assessments of radiation exposure. For
a large mass-casualty event involving exposure to ionizing radiation, it is of utmost …

Validation of the cytokinesis-block micronucleus assay using imaging flow cytometry for high throughput radiation biodosimetry

MA Rodrigues, LA Beaton-Green, RC Wilkins - Health Physics, 2016 - journals.lww.com
The cytokinesis-block micronucleus assay can be employed in triage radiation biodosimetry
to determine the dose of radiation to an exposed individual by quantifying the frequency of …

Laboratory intercomparison of the cytokinesis-block micronucleus assay

H Romm, S Barnard, H Boulay-Greene… - Radiation …, 2013 - meridian.allenpress.com
The focus of the study is an intercomparison of laboratories' dose-assessment performances
using the cytokinesis-block micronucleus (CBMN) assay as a diagnostic triage tool for …

The cytokinesis-blocked micronucleus assay: dose–response calibration curve, background frequency in the population and dose estimation

E Rastkhah, F Zakeri, M Ghoranneviss… - Radiation and …, 2016 - Springer
An in vitro study of the dose responses of human peripheral blood lymphocytes was
conducted with the aim of creating calibrated dose–response curves for biodosimetry …

Assay of micronuclei in peripheral blood lymphocytes as a biological indicator of radiation dose

B Sreedevi, BS Rao - Radiation protection dosimetry, 1994 - academic.oup.com
Chromosomal aberration analysis (CA) has regularly been used as a biological dosemeter
to evaluate suspected overexposures to ionising radiations. Recently, the micronucleus …

Validation of the cytokinesis-block micronucleus (CBMN) assay for use as a triage biological dosimetry tool

JP McNamee, FN Flegal, HB Greene… - Radiation protection …, 2009 - academic.oup.com
Traditionally, the dicentric chromosome assay (DCA) has been used to derive biological
dose estimates for unknown radiological exposures. While sensitive, this assay requires …

Adaption of the cytokinesis-block micronucleus cytome assay for improved triage biodosimetry

C Beinke, M Port, A Riecke, CG Ruf… - Radiation …, 2016 - meridian.allenpress.com
The purpose of this work was to adapt a more advanced form of the cytokinesis-block
micronucleus (CBMN) cytome assay for triage biodosimetry in the event of a mass casualty …

Monitoring of human exposure to radiation with the binucleated lymphocyte micronucleus assay.

JL He, HY Jin, LF Jin, SY Gao - Biomedical and Environmental …, 2000 - europepmc.org
The micronuclei (MN) of peripheral blood lymphocytes from radiation-exposed people were
monitored with the binucleated lymphocyte micronucleus assay (CBMN). MN rates in people …

Application of the Cytokinesis-Block Micronucleus Assay for High-Dose Exposures Using Imaging Flow Cytometry

EMHSC Sancheza, R Darwisha… - Cytogenet Genome …, 2023 - karger.com
The cytokinesis-block micronucleus assay is a wellestablished method to assess radiation-
induced genetic damage in human cells. This assay has been adapted to imaging flow …