Cancer‐Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress‐Induced Apoptosis via METTL3 Mediated m6A Methylation of COL10A1

Y Li, X Li, M Deng, C Ye, Y Peng… - Oxidative medicine and …, 2022 - Wiley Online Library
Background. Cancer‐associated fibroblasts (CAFs) within the tumor microenvironment are
key players in tumorigenesis and tumor development. Nevertheless, the regulatory …

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …

Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression

S Li, X Lu, D Zheng, W Chen, Y Li, F Li - Journal of Cancer Research and …, 2022 - Springer
Objective Lung cancer (LC) remains a threatening health issue worldwide.
Methyltransferase-like protein 3 (METTL3) is imperative in carcinogenesis via m6A …

RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma

Y Cui, C Zhang, S Ma, Z Li, W Wang, Y Li, Y Ma… - Journal of Experimental …, 2021 - Springer
Background Long non-coding RNA (LncRNA) controls cell proliferation and plays a
significant role in the initiation and progression of esophageal squamous cell carcinoma …

The multifaceted roles of COL4A4 in lung adenocarcinoma: An integrated bioinformatics and experimental study

T Zheng, Z Zheng, H Zhou, Y Guo, S Li - Computers in Biology and …, 2024 - Elsevier
Background Abnormal expression of collagen IV subunits has been reported in cancers, but
the significance is not clear. No study has reported the significance of COL4A4 in lung …

[HTML][HTML] Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m6A modification

M Chen, Q Zhang, S Zheng, X Guo, L Cao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cancer progression depends on the communication between tumor cells and tumor
microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of stromal …

M5C-related lncRNA predicts lung adenocarcinoma and tumor microenvironment remodeling: computational biology and basic science

M Bai, C Sun - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Purpose: Epigenetic RNA modification regulates gene expression post-transcriptionally. The
aim of this study was to construct a prognostic risk model for lung adenocarcinoma (LUAD) …

FTO-mediated LINC01134 stabilization to promote chemoresistance through miR-140-3p/WNT5A/WNT pathway in PDAC

J Lu, Y Yang, X Liu, X Chen, W Song, Z Liu - Cell Death & Disease, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer most frequently
detected at an advanced stage that limits treatment options to systemic chemotherapy, which …

[HTML][HTML] METTL7B serves as a prognostic biomarker and promotes metastasis of lung adenocarcinoma cells

R Li, C Mu, Y Cao, Y Fan - Annals of Translational Medicine, 2022 - ncbi.nlm.nih.gov
Background To research the correlation between the prognosis of patients suffering from
lung adenocarcinoma (LUAD) and methyltransferase like 7B (METTL7B) expression …

[HTML][HTML] METTL3 facilitates tumor progression by COL12A1/MAPK signaling pathway in esophageal squamous cell carcinoma

J Li, Z Li, Y Xu, C Huang, B Shan - Journal of Cancer, 2022 - ncbi.nlm.nih.gov
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common
aggressive tumors in the world. m6A modification has been implicated to play an important …