Despite the large amounts of H 2 O 2 generated in mammalian peroxisomes, cysteine
residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry …

Despite intensive research on peroxisome biochemistry, the role of glutathione in
peroxisomal redox homeostasis has remained a matter of speculation for many years, and …

Peroxisomes are highly dynamic intracellular organelles involved in a variety of metabolic
functions essential for the metabolism of long-chain fatty acids, d-amino acids, and many …

Reactive oxygen species (ROS) are at once unsought by-products of metabolism and critical
regulators of multiple intracellular signaling cascades. In nonphotosynthetic eukaryotic cells …

Peroxisomes are ubiquitous “multipurpose” organelles of eukaryotic cells. Their matrix
enzymes catalyze mainly catabolic and anabolic reactions of lipid metabolism, thus …

Peroxisomes serve as important centers for cellular redox metabolism and communication.
However, fundamental gaps remain in our understanding of how the peroxisomal redox …

The functional role of the peroxisomal membrane as a permeability barrier to metabolites
has been a matter of controversy for more than four decades. The initial conception, claiming …

Peroxisomes perform a range of metabolic functions which require the movement of
substrates, co-substrates, cofactors and metabolites across the peroxisomal membrane. In …

One of the many functions of liver peroxisomes is the β-oxidation of long-chain fatty acids. It
is essential for the continuation of peroxisomal β-oxidation that a redox shuttle system exist …

Aims: Peroxisomes are ubiquitous, single-membrane-bounded organelles that contain
considerable amounts of enzymes involved in the production or breakdown of hydrogen …