Drug conjugates for targeting regulatory T cells in the tumor microenvironment: guided missiles for cancer treatment
J Yang, H Bae - Experimental & Molecular Medicine, 2023 - nature.com
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in
suppressing anticancer immune responses; therefore, various strategies targeting Tregs are …
suppressing anticancer immune responses; therefore, various strategies targeting Tregs are …
Regulatory T cell targeting in cancer: Emerging strategies in immunotherapy
S Dees, R Ganesan, S Singh… - European Journal of …, 2021 - Wiley Online Library
The adaptive immune system is modulated by an important subset of CD4+ T lymphocytes
called Treg cells that function in maintaining immune homeostasis by preventing excessive …
called Treg cells that function in maintaining immune homeostasis by preventing excessive …
In Vivo Targeting of Intratumor Regulatory T Cells Using PEG-Modified Single-Walled Carbon Nanotubes
C Sacchetti, N Rapini, A Magrini, E Cirelli… - Bioconjugate …, 2013 - ACS Publications
Recent evidence regarding the role of regulatory T cells (Treg) in tumor development has
suggested that the manipulation of Treg function selectively in the tumor microenvironment …
suggested that the manipulation of Treg function selectively in the tumor microenvironment …
Treg programming and therapeutic reprogramming in cancer
MA Moreno Ayala, Z Li, M DuPage - Immunology, 2019 - Wiley Online Library
Overcoming the immunosuppressive tumour microenvironment is the major challenge
impeding cancer immunotherapy today. Regulatory T‐cells (Tregs) are prevalent in nearly …
impeding cancer immunotherapy today. Regulatory T‐cells (Tregs) are prevalent in nearly …
Targeting tumor-infiltrating tregs for improved antitumor responses
D Qin, Y Zhang, P Shu, Y Lei, X Li, Y Wang - Frontiers in Immunology, 2024 - frontiersin.org
Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells
(Tregs), as crucial components of the tumor immune environment, has great therapeutic …
(Tregs), as crucial components of the tumor immune environment, has great therapeutic …
Regulating the regulatory T cells as cell therapies in autoimmunity and cancer
H Hosseinalizadeh, F Rabiee, N Eghbalifard… - Frontiers in …, 2023 - frontiersin.org
Regulatory T cells (Tregs), possess a pivotal function in the maintenance of immune
homeostasis. The dysregulated activity of Tregs has been associated with the onset of …
homeostasis. The dysregulated activity of Tregs has been associated with the onset of …
[HTML][HTML] Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies
S Koyama, H Nishikawa - Journal for immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
Therapeutic targeting of regulatory T cells in cancer
F Shan, A Somasundaram, TC Bruno, CJ Workman… - Trends in cancer, 2022 - cell.com
The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
Nanodrugs targeting T cells in tumor therapy
M Haist, V Mailänder, M Bros - Frontiers in Immunology, 2022 - frontiersin.org
In contrast to conventional anti-tumor agents, nano-carriers allow co-delivery of distinct
drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic …
drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic …
Tumor stroma–targeted antibody-drug conjugate triggers localized anticancer drug release
C Szot, S Saha, XM Zhang, Z Zhu… - The Journal of …, 2018 - Am Soc Clin Investig
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a
solid tumor mass, better strategies to exploit these cells for improved cancer therapy are …
solid tumor mass, better strategies to exploit these cells for improved cancer therapy are …
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