The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
Potency, safety, and pharmacokinetic profiles of potential inhibitors targeting SARS-CoV-2 main protease
Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the
ongoing COVID-19 pandemic. The main protease or 3C-like protease (Mpro or 3CLpro) of …
ongoing COVID-19 pandemic. The main protease or 3C-like protease (Mpro or 3CLpro) of …
Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Expedited approach toward the rational design of noncovalent SARS-CoV-2 main protease inhibitors
The main protease (Mpro) of SARS-CoV-2 is a validated antiviral drug target. Several Mpro
inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity …
inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity …
Discovery and mechanism study of SARS-CoV-2 3c-like protease inhibitors with a new reactive group
P Ren, H Li, T Nie, X Jian, C Yu, J Li, H Su… - Journal of Medicinal …, 2023 - ACS Publications
3CLpro is an attractive target for the treatment of COVID-19. Using the scaffold hopping
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …
Perspectives on SARS-CoV-2 main protease inhibitors
The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
Small-molecule thioesters as SARS-CoV-2 main protease inhibitors: enzyme inhibition, structure–activity relationships, antiviral activity, and X-ray structure …
T Pillaiyar, P Flury, N Krüger, H Su… - Journal of Medicinal …, 2022 - ACS Publications
The main protease (Mpro, 3CLpro) of SARS-CoV-2 is an attractive target in coronaviruses
because of its crucial involvement in viral replication and transcription. Here, we report on …
because of its crucial involvement in viral replication and transcription. Here, we report on …
Structural basis of potential inhibitors targeting SARS-CoV-2 main protease
The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing
significant social, economic, and political chaos. Corresponding to the absence of globally …
significant social, economic, and political chaos. Corresponding to the absence of globally …
A review of the latest research on M pro targeting SARS-COV inhibitors
H Yang, J Yang - RSC medicinal chemistry, 2021 - pubs.rsc.org
Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still
spreading at an alarming rate and has caused huge loss of life and economic damage …
spreading at an alarming rate and has caused huge loss of life and economic damage …
Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19
The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by
severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS) …
severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS) …
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