Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

Neuropathic pain is caused by lesion or dysfunction of the peripheral sensory nervous
system. Up-regulation of the voltage-gated Ca2+ channel subunit α2δ-1 in DRG (dorsal root …

Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin
(“gabapentinoids”) were engineered to mimic the action of GABA and to modulate GABA …

The gabapentinoid drugs gabapentin and pregabalin (Neurontin and Lyrica) are mainstay
treatments for neuropathic pain and preventing focal seizures. Both drugs have similar …

Neuropathic pain is a debilitating condition affecting millions of people around the world and
is defined as pain that follows a lesion or dysfunction of the nervous system. This type of …

Gabapentin (Neurontin®) and pregabalin (Lyrica®) comprise an interesting class of drugs
for chronic pain. These drugs differ structurally and mechanistically from other analgesics …

Gabapentin (Neurontin, Pfizer Canada Inc) and pregabalin (Lyrica, Pfizer Canada Inc) were
initially developed as antiepileptic drugs and were later discovered to be effective in the …

Pregabalin 1 was recently approved in the US and Europe as an add-on therapy for
epilepsy, as well as for the treatment of neuropathic pain (specifically, management of …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …