Protein–protein interactions sequester enzymes close to their substrates. Protein kinase C
(PKC) is one example of a ubiquitous signaling molecule with effects that are dependent …

Protein Kinase C (PKC) is a family of serine–threonine kinases found in most cell types
whose activity has a strong influence on a wide variety of signal transduction events …

PKC (protein kinase C) isoenzymes are related protein kinases, involved in many signalling
events in normal state and in disease. Basic research into identifying the molecular basis of …

In cells, signal transduction often occurs within “signaling complexes” where physical
associations among several enzymes are coordinated by scaffold proteins. 1 The scaffold is …

Conventional and novel protein kinase C (PKC) isozymes contain two cysteine-rich C1
domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu) …

Protein kinase C (PKC) is a phospholipid-dependent isozyme family that plays a pivotal role
in mammalian signal-transduction pathways that mediate cell growth and differentiation and …

Phosphorylation by protein kinases is a central theme in biological systems. Aberrant protein
kinase activity has been implicated in a variety of human diseases, therefore, modulation of …

Protein kinase C (PKC) is a family of kinases that are critical in many cellular events. These
enzymes are activated by lipid-derived second messengers, are dependent on binding to …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …

A potent and highly selective inhibitor of protein kinase C α has been generated via the
combinatorial modification of a consensus sequence peptide. The inhibitor displays a K i of …