Aging entails a progressive decline of cognitive abilities. However, since the brain is
endowed with considerable plasticity, adequate stimulation can delay or partially …

The main aim of this chapter is to review preclinical studies that have evaluated
interventions which may aid in preventing or delaying age-related behavioural decline …

Environmental enrichment has become increasingly utilized in rodent models of aging and
neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal …

The rescue of cognitive function through environmental enrichment (EE) during aging has
been extensively documented. However, the age at onset, the duration of EE, and the …

Environmental manipulations enhance neuroplasticity, with enrichment-induced cognitive
improvements linked to increased expression of growth factors and enhanced hippocampal …

Aging-associated brain changes include functional alterations that are usually related with
memory decline. Epidemiological reports show that a physically and intellectually active life …

Environmental enrichment (EE) is an experimental paradigm that is used to explore how a
complex, stimulating environment can impact overall health. In laboratory animal …

Background: In recent decades, the interest in behavioral interventions has been growing
due to the higher prevalence of age-related cognitive impairments. Hence, behavioral …

Progression of cognitive decline with or without neurodegeneration varies among elderly
subjects. The main aim of the current study was to illuminate the molecular mechanisms that …

With the aging of the world population, there has been a notable increase in the incidence of
Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly …