Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing
dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS …

In growing cells, DNA replication precedes mitotic cell division to transmit genetic
information to the next generation. The slowing or stalling of DNA replication forks at natural …

Accurate replication of DNA requires stringent regulation to ensure genome integrity. In
human cells, thousands of origins of replication are coordinately activated during S phase …

Replication and transcription are key aspects of DNA metabolism that take place on the
same template and potentially interfere with each other. Conflicts between these two …

DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …

DNA and RNA polymerases clash along the genome as they compete for the same DNA
template. Cells have evolved specialized strategies to prevent and resolve replication and …

Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous
and exogenous sources. Specialized DNA replication stress response pathways ensure …

Half of the human genome is made up of repetitive DNA. However, mechanisms underlying
replication of chromosome regions containing repetitive DNA are poorly understood. We …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …