Cross-talk between NADPH oxidase and mitochondria: role in ROS signaling and angiogenesis

T Fukai, M Ushio-Fukai - Cells, 2020 - mdpi.com
Angiogenesis, a new vessel formation from the pre-existing ones, is essential for embryonic
development, wound repair and treatment of ischemic heart and limb diseases. However …

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

YM Kim, SJ Kim, R Tatsunami… - … of Physiology-Cell …, 2017 - journals.physiology.org
Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) and mitochondria play
a critical role in growth factor-induced switch from a quiescent to an angiogenic phenotype …

VEGF signaling through NADPH oxidase-derived ROS

M Ushio–Fukai - Antioxidants & redox signaling, 2007 - liebertpub.com
Angiogenesis is a key process involved in normal development and wound repair, as well
as ischemic heart and limb diseases, and atherosclerosis. Vascular endothelial growth …

Compartmentalization of redox signaling through NADPH oxidase–derived ROS

M Ushio-Fukai - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen species (ROS) are generated in response to growth factors, cytokines, G
protein–coupled receptor agonists, or shear stress, and function as signaling molecules in …

Redox signaling in angiogenesis: role of NADPH oxidase

M Ushio-Fukai - Cardiovascular research, 2006 - academic.oup.com
Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Downstream targets and intracellular compartmentalization in Nox signaling

K Chen, SE Craige, JF Keaney Jr - Antioxidants & redox signaling, 2009 - liebertpub.com
Reactive oxygen species (ROS) have become recognized for their role as second
messengers in a multitude of physiologic responses. Emerging evidence points to the …

[HTML][HTML] NOX isoforms and reactive oxygen species in vascular health

RM Touyz, AM Briones, M Sedeek… - Molecular …, 2011 - triggered.edina.clockss.org
Reactive oxygen species (ROS) are important mediators of cell growth, adhesion,
differentiation, migration, senescence, and apoptosis. ROS play an important physiological …

[HTML][HTML] Mitochondria in endothelial cells: Sensors and integrators of environmental cues

S Caja, JA Enríquez - Redox biology, 2017 - Elsevier
The involvement of angiogenesis in disease and its potential as a therapeutic target have
been firmly established over recent decades. Endothelial cells (ECs) are central elements in …

Mitochondrial ROS regulation of proliferating cells

L Diebold, NS Chandel - Free Radical Biology and Medicine, 2016 - Elsevier
Once thought of exclusively as damaging molecules, reactive oxygen species (ROS) are
becoming increasingly appreciated for the role they play in cellular signaling through redox …

The ROS-NOX connection in cancer and angiogenesis

C Blanchetot, J Boonstra - Critical Reviews™ in Eukaryotic …, 2008 - dl.begellhouse.com
Initially viewed as dangerous byproducts of aerobic life, reactive oxygen species (ROS)
nowadays appear to be essential secondary messengers of many signaling cascades and …