Acute pancreatitis (AP) is a common emergency of the digestive system and serious cases
can develop into severe acute pancreatitis (SAP), which ortality rates up to 30%. Sirtuin4 …

Pancreatic cancer (PC) is a malignant tumor with high mortality worldwide. SIRT6 plays
versatile roles in human cancers. However, SIRT6 has rarely been studied in PC. The …

Background Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1
(SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in …

Recently, SIRT5 was reported to be a predominant desuccinylase and demalonylase in
mitochondria. Ablation of SIRT5 enhances the systemic succinylation and malonylation of …

The sirtuin family has been reported to participate in the regulation of oxidative stress,
cancer metabolism, aging, and so on. However, few studies have demonstrated its role in …

Ferroptosis, an autophagy‐dependent cell death, is characterized by lipid peroxidation and
iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus …

Insufficient insulin produced by pancreatic β-cells in the control of blood sugar is a central
feature of the etiology of diabetes. Reports have shown that endoplasmic reticulum (ER) …

Background Severe burns are often complicated with hyperglycemia caused by
mitochondrial oxidative stress-related pancreatic islet dysfunction. Silent information …

Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced
by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited …

Oxidative stress and endoplasmic reticulum (ER) stress play crucial roles in pancreatic β cell
destruction, leading to the development and progression of type 1 diabetes mellitus (T1DM) …