MUTYH gene is involved in the base excision repair (BER) mechanism and its pathogenic
alterations are associated with colorectal polyposis and cancer. MUTYH-associated …

MUTYH-associated polyposis (MAP) was first described in 2002. MUTYH is a component of
a base excision repair system that protects the genomic information from oxidative damage …

In 2002, Al-Tassan and co-workers described for the first time a recessive form of inherited
polyposis associated with germline mutations of MUTYH, a gene encoding a base excision …

MUTYH-associated polyposis (MAP) was first described in 2002. It is an autosomal
recessive condition associated with germline pathogenic variants of both MUTYH alleles. In …

BACKGROUND & AIMS: Biallelic mutations in the base excision DNA repair gene MUTYH
lead to MUTYH-associated polyposis (MAP) and predisposition to colorectal cancer (CRC) …

The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and
colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene …

Established predisposition genes account for only a small proportion of familial colorectal
cancer. Recently, it has been shown that germline mutations in MUTYH predispose to …

Introduction MUTYH-associated polyposis (MAP) is an autosomal recessive cancer
predisposition syndrome associated with the development of colorectal tumors and colonic …

MUTYH is a base excision repair enzyme, it plays a crucial role in the correction of DNA
errors from guanine oxidation and may be considered a cell protective factor. In humans it is …

MUTYH encodes a glycosylase involved in the base excision repair of DNA. Biallelic
pathogenic germline variants in MUTYH cause an autosomal recessive condition known as …