All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA

X Leng, JJ Kinnun, AT Cavazos, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Eicosapentaenoic (EPA, 20: 5), docosahexaenoic (DHA, 22: 6) and
docosapentaenoic (DPA, 22: 5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) …

[HTML][HTML] How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

SR Shaikh, JJ Kinnun, X Leng, JA Williams… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Marine long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic (EPA) and
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …

Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids

SR Shaikh, DA Brown - Prostaglandins, Leukotrienes and Essential Fatty …, 2013 - Elsevier
Bioactive n-3 polyunsaturated fatty acids (PUFA), abundant in fish oil, have potential for
treating symptoms associated with inflammatory and metabolic disorders; therefore, it is …

Molecular organization of a raft-like domain in a polyunsaturated phospholipid bilayer: A supervised machine learning analysis of molecular dynamics simulations

SW Canner, SE Feller, SR Wassall - The Journal of Physical …, 2021 - ACS Publications
Numerous health benefits are associated with omega-3 polyunsaturated fatty acids (n-3
PUFA) consumed in fish oils. An understanding of the mechanism remains elusive. The …

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …

[HTML][HTML] Polyunsaturated fatty acid–cholesterol interactions: domain formation in membranes

SR Wassall, W Stillwell - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Polyunsaturated fatty acids (PUFA) constitute an influential group of molecules that promote
health by an as yet unknown mechanism. They are structurally distinguished from less …

EPA and DHA containing phospholipids have contrasting effects on membrane structure

SCR Sherratt, RA Juliano, C Copland, DL Bhatt… - Journal of Lipid …, 2021 - ASBMB
Abstract Omega-3 FAs EPA and DHA influence membrane fluidity, lipid rafts, and signal
transduction. A clinical trial, Reduction of Cardiovascular Events with Icosapent Ethyl …

Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …

Cholesterol in bilayers with PUFA chains: doping with DMPC or POPC results in sterol reorientation and membrane-domain formation

N Kucerka, D Marquardt, TA Harroun, MP Nieh… - Biochemistry, 2010 - ACS Publications
Using neutron diffraction Harroun et al.[(2006) Biochemistry 45, 1227− 1233;(2008)
Biochemistry 47, 7090− 7096] carried out studies that unequivocally demonstrated …

Influence of very-long-chain polyunsaturated fatty acids on membrane structure and dynamics

V Cheng, R Rallabandi, A Gorusupudi, S Lucas… - Biophysical journal, 2022 - cell.com
The unique attributes of very-long-chain polyunsaturated fatty acids (VLC-PUFAs), their long
carbon chains (n> 24) and high degree of unsaturation, impart unique chemical and …