Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …

[HTML][HTML] The relationships between stress, mental disorders, and epigenetic regulation of BDNF

Z Miao, Y Wang, Z Sun - International journal of molecular sciences, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays
an important role in multiple stress-related mental disorders. Although alterations in BDNF in …

Hippocampal BDNF in physiological conditions and social isolation

I Zaletel, D Filipović, N Puškaš - Reviews in the Neurosciences, 2017 - degruyter.com
Exposure of an organism to chronic psychosocial stress may affect brain-derived
neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric …

Synaptic regulation of affective behaviors; role of BDNF

I Ninan - Neuropharmacology, 2014 - Elsevier
Brain derived neurotrophic factor (BDNF), a neurotrophin essential for nervous system
development and synaptic plasticity, has been found to have a significant influence on …

A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder

B Hing, L Sathyaputri, JB Potash - American Journal of Medical …, 2018 - Wiley Online Library
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …

Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress

Y Ibarguen-Vargas, A Surget, P Vourc'h… - Behavioural brain …, 2009 - Elsevier
Despite growing evidences of an association between brain-derived neurotrophic factor
(BDNF) and antidepressant effects, the neurotrophic hypothesis of depression is challenged …

[HTML][HTML] Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the …

A Nair, KC Vadodaria, SB Banerjee… - …, 2007 - nature.com
Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the
hippocampal damage observed in depression. BDNF has a complex gene structure with …

Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

MH Larsen, JD Mikkelsen, A Hay-Schmidt… - Journal of psychiatric …, 2010 - Elsevier
Chronic unpredictable stress (CUS) is a widely used animal model of depression. The
present study was undertaken to investigate behavioral, physiological and molecular effects …

New insights into BDNF function in depression and anxiety

K Martinowich, H Manji, B Lu - Nature neuroscience, 2007 - nature.com
The'neurotrophin hypothesis of depression'is based largely on correlations between stress
or antidepressant treatment and down-or upregulation, respectively, of brain-derived …