Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …

Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator
(CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH …

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and …

In cystic fibrosis (CF), absence or dysfunction of a phosphorylation-regulated chloride
channel [CF transmembrane conductance regulator (CFTR)] leads to the loss or reduction of …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in
defective epithelial cAMP-dependent Cl− secretion and increased airway Na+ absorption …

The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an
adenosine 3′, 5′-monophosphate (cyclic AMP)—activated chloride channel. In cystic …

Cystic fibrosis (CF) patients are hypersusceptible to chronic Pseudomonas aeruginosa lung
infections. Cultured human airway epithelial cells expressing the ΔF508 allele of the cystic …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel
regulated by protein kinase A and adenosine triphosphate (ATP). Loss of CFTR-mediated …

Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-
dependent chloride ion channel known as the cystic fibrosis transmembrane conductance …

Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl− channels. However, it is not
understood how this defect disrupts salt and liquid movement in the airway or whether it …