The discovery of AQP4‐IgG (a pathogenic antibody that targets the astrocytic water channel
aquaporin‐4), as the first sensitive and specific biomarker for any inflammatory central …

Neuromyelitis optica (NMO) spectrum disorders (SD) represent an evolving group of central
nervous system (CNS)-inflammatory autoimmune demyelinating diseases unified by a …

Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of
the CNS for which a specific tissue target molecule has been identified—the astrocytic water …

Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are
unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water …

The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a
spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying …

Abstract Aquaporin‐4 (AQP 4) is a water channel protein that is most highly, but not
exclusively, expressed in the central nervous system. In 2005 AQP 4 was shown to be the …

Neuromyelitis optica spectrum disorders (NMOSD) is a heterogeneous group of
neuroinflammatory conditions associated with demyelination primarily in spinal cord and …

Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

Neuromyelitis optica (NMO) is an autoimmune 'aquaporinopathy'of the central nervous
system that causes inflammatory demyelinating lesions primarily in spinal cord and optic …