The curative treatment options for papillary thyroid cancer (PTC) encompass surgical
intervention, radioactive iodine administration, and chemotherapy. However, the challenges …

Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor
prognosis. Hypoxia‐inducible factor‐1 is a transcription factor activated by hypoxia that …

Background Tumor cells adapt to hypoxia by regulating transcription factors that involved in
regulation of metabolism, angiogenesis, cell proliferation, and apoptosis. Under hypoxic …

Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various
cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or …

Background and purpose Undifferentiated follicular and anaplastic thyroid tumours often
respond poorly to radiotherapy and show increased metastatic potential. We evaluated …

Abstract Context: Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-
inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with …

Background/Aim: Despite an excellent prognosis, certain patients with thyroid cancer suffer
from locally invasive disease that cannot be controlled by conventional therapy. Our …

Hypoxia-inducible factor 1α (HIF-1α) is upregulated by hypoxia and oncogenic signalling in
many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We …

Adaptation to hypoxia is an important process physiologically and pathologically. Hypoxia-
inducible factor-1α (HIF-1α) participates in the cancer biology of numerous endocrine …

Objective To investigate the value of Hypoxia-inducible factor 1 A (HIF1A) in predicting
lymph node metastasis (LNM) stage and clinical outcomes of papillary thyroid cancer (PTC) …