Much evidence suggests a protective role of high-density lipoprotein (HDL) and its major
apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived …

Recent studies suggest that apolipoprotein AI (ApoA-I), the major protein constituent of high-
density lipoprotein particles, plays a critical role in preserving cerebrovascular integrity and …

Although apolipoprotein E (apoE) is the most common genetic risk factor for Alzheimer's
Disease (AD), how apoE participates in AD pathogenesis remains incompletely understood …

Defective clearance of the amyloid‐β peptide (Aβ) from the brain is considered a strong
promoter in Alzheimer's disease (AD) pathogenesis. Astrocytes and microglia are important …

Background: While apolipoprotein E4 (apoE4) is highly correlated with the development of
Alzheimer's disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) …

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the
accumulation of extracellular plaques and intracellular tangles. Recent studies support the …

Background Alzheimer's disease (AD) is defined by amyloid beta (Aβ) plaques and
neurofibrillary tangles and characterized by neurodegeneration and memory loss. The …

Amyloid-β (Aβ) accumulation in Alzheimer's disease (AD) and cerebral amyloid angiopathy
(CAA) is likely caused by the impairment of its brain clearance that partly occurs through the …

Lipoprotein metabolism in the central nervous system (CNS) is based on high-density
lipoprotein-like particles that use apoE as their predominant apolipoprotein rather than apoA …

Amyloid β-peptide (Aβ) clearance from the central nervous system (CNS) maintains its low
levels in brain. In Alzheimer's disease, Aβ accumulates in brain possibly because of its faulty …