The courses of six patients with adenosine deaminase (ADA) and two with purine
nucleoside phosphorylase (PNP) deficiencies were evaluated before and after therapy. The …

Severe Combined Immunodeficiency (SCID) is a fatal disorder of infancy in which patients
exhibit profound defects of both cellular and humoral immune function. Approximately 50 …

The serendipitous finding of adenosine deaminase (ADA) deficiency in patients with severe
combined immunodeficiency disease led to the speculation that patients with inherited …

A patient with a selective impairment of T cell-dependent immunity based on a purine
nucleoside phosphorylase (PNP) deficiency has been treated with transfusions of irradiated …

Purine nucleoside phosphorylase deficiency in association with immunodeficiency is a
distinctive immunological disorder. A total of nine patients, in six different institutions, have …

DEFICIENCY of the purine enzyme nucleoside phosphorylase is associated with a severe T-
lymphocyte immune deficiency. 1 2 3 4 5 6 The abnormality in the immune system results …

The clinical presentations of adenosine deaminase deficiency and purine nucleoside
phosphorylase deficiency are widely variable and include clinical and immunologic findings …

The fourth edition of Dr. Max Wintrobe's textbook Clinical Hematology,'published in 1956,
contained only three pages describing the lymphocyte and speculating about its function. At …

The current classification of immunodeficiency disorders can be considered analogous to
the state of classification of pneumonias during the early days of application of …

Addition of adenosine deaminase (ADA) restored in vitro responses of lymphocytes from a
patient with ADA deficiency and severe combined immunodeficiency (SCID). Enzyme …