Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

GS Palanisamy, EE Smith, CA Shanley, DJ Ordway… - Tuberculosis, 2008 - Elsevier
Virulence is the measure of pathogenicity of a microorganism as determined by its ability to
invade host tissues and to produce severe disease. In the low-dose aerosol guinea pig …

A Comparative Study of the Virulence of Mycobacterium Tuberculosis Measured in Mice and Guinea Pigs

FM Collins, MM Smith - American Review of Respiratory Disease, 1969 - atsjournals.org
Mycobacterium tuberculosis strains Erdman, H37Rv, and H37Ra, as well as M. bovis (BCG
Tice), were grown on Tween®-albumin, Proskauer and Beck, or American Trudeau Society …

Virulence ranking of some Mycobacterium tuberculosis and Mycobacterium bovis strains according to their ability to multiply in the lungs, induce lung pathology, and …

PL Dunn, RJ North - Infection and immunity, 1995 - Am Soc Microbiol
Three virulent strains of Mycobacterium tuberculosis (H37Rv, Erdman, and NYH-27) and two
virulent strains of M. bovis (Ravenel and Branch) were compared in terms of their growth …

Growth of a highly virulent strain of Mycobacterium tuberculosis in mice of differing susceptibility to tuberculous challenge

CL Kelley, FM Collins - Tubercle and Lung Disease, 1999 - Elsevier
Mycobacterium tuberculosis strain CDC 1551 exhibited unusually high levels of infectivity
and virulence during a recent outbreak of tuberculosis in a rural community. Mice infected …

Comparable Growth of Virulent and Avirulent Mycobacterium tuberculosis in Human Macrophages In Vitro

S Paul, P Laochumroonvorapong… - Journal of Infectious …, 1996 - academic.oup.com
The relative virulence and avirulence of Mycobacterium tuberculosis strains H37Rv and
H37Ra were previously defined using animal infection models. To investigate host species' …

In Vivo Phenotypic Dominance in Mouse Mixed Infections with Mycobacterium tuberculosis Clinical Isolates

AK Barczak, P Domenech, HIM Boshoff… - The Journal of …, 2005 - academic.oup.com
Clinical isolates of Mycobacterium tuberculosis demonstrate significant heterogeneity in
virulence potential in animal models of infection. Isolate CDC1551, for example, has …

An assay to compare the infectivity of Mycobacterium tuberculosis isolates based on aerosol infection of guinea pigs and assessment of bacteriology

A Williams, BW James, J Bacon, KA Hatch, GJ Hatch… - Tuberculosis, 2005 - Elsevier
The aim of this study was to establish an assay to compare Mycobacterium tuberculosis
strains, and cells grown under different growth conditions, in terms of their ability to cause a …

Persistent infection with virulent but not avirulent Mycobacterium tuberculosis in the lungs of mice causes progressive pathology

PL Dunn, RJ North - Journal of medical microbiology, 1996 - microbiologyresearch.org
A strain of Mycobacterium tuberculosis (H37Rv) considered virulent for mice and a strain
(R1Rv) considered relatively avirulent were compared for their ability to survive host …

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug …

DR Hoff, GJ Ryan, ER Driver, CC Ssemakulu… - PloS one, 2011 - journals.plos.org
The lengthy treatment regimen for tuberculosis is necessary to eradicate a small sub-
population of M. tuberculosis that persists in certain host locations under drug pressure …

An Outbreak Involving Extensive Transmission of a Virulent Strain of Mycobacterium tuberculosis

SE Valway, MPC Sanchez, TF Shinnick… - … England Journal of …, 1998 - Mass Medical Soc
Background and Methods From 1994 to 1996, there was a large outbreak of tuberculosis in
a small, rural community with a population at low risk for tuberculosis. Twenty-one patients …