Abstract Synphilin-1, a cytoplasmic protein, interacts with α-synuclein which is one of the
main constituents of Lewy bodies and plays an important role in the pathology of Parkinson's …

Synphilin-1 is a cytoplasmic protein with unclear function. Synphilin-1 has been identified as
an interaction partner of α-synuclein. The interaction between synphilin-1 and α-synuclein …

Synphilin-1 represents a cytoplasmic protein that interacts with α-synuclein and localizes
close to synaptic vesicles. The interaction of synphilin-1 with several proteins involved in …

Parkinson's disease (PD) is characterized by the death of dopaminergic neurons and the
presence of Lewy bodies in the substantia nigra pars compacta. The mechanisms involved …

Parkinson disease is the second most frequent neurodegenerative disorder after Alzheimer
disease. A subset of genetic forms of Parkinson disease has been attributed to α-synuclein …

A common finding in many neurodegenerative diseases is the presence of inclusion bodies
made of aggregated proteins in neurons of affected brain regions. In Parkinson's disease …

Synphilin‐1 was described as a protein interacting with α‐synuclein and is commonly found
in Lewy bodies, the pathological hallmark of Parkinson's disease (PD). Our group has …

The name synphilin-1 comes from its identification as an alpha-synuclein-interacting protein
(SNCAIP) in yeast two-hybrid screens. Since alpha-synuclein (PARK1) was the first gene …

Background Parkinson's disease is characterized by the presence of cytoplasmic inclusions,
known as Lewy bodies, containing both aggregated α-synuclein and its interaction partner …

Genetic alterations in α-synuclein cause autosomal dominant familial Parkinsonism and may
contribute to sporadic Parkinson's disease (PD). Synphilin-1 is an α-synuclein-interacting …