Epithelial ovarian cancer experimental models

E Lengyel, JE Burdette, HA Kenny, D Matei, J Pilrose… - Oncogene, 2014 - nature.com
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …

Emerging and evolving ovarian cancer animal models

AS Bobbs, JM Cole, KDC Dahl - Cancer growth and …, 2015 - journals.sagepub.com
Ovarian cancer (OC) is the leading cause of death from a gynecological malignancy in the
United States. By the time a woman is diagnosed with OC, the tumor has usually …

Models of ovarian cancer—are we there yet?

K Garson, TJ Shaw, KV Clark, DS Yao… - Molecular and cellular …, 2005 - Elsevier
Ovarian cancer is the most lethal of all gynecological cancers and arises most commonly
from the surface epithelium. Successful clinical management of patients with epithelial …

Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis

RB Bankert, SV Balu-Iyer, K Odunsi, LD Shultz… - PloS one, 2011 - journals.plos.org
Ovarian cancer is the most common cause of death from gynecological cancer.
Understanding the biology of this disease, particularly how tumor-associated lymphocytes …

Current insights into the metastasis of epithelial ovarian cancer-hopes and hurdles

M Yousefi, S Dehghani, R Nosrati, M Ghanei… - Cellular Oncology, 2020 - Springer
Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …

The latest animal models of ovarian cancer for novel drug discovery

E Magnotti, WA Marasco - Expert opinion on drug discovery, 2018 - Taylor & Francis
Introduction: Epithelial ovarian cancer is a heterogeneous disease classified into five
subtypes, each with a different molecular profile. Most cases of ovarian cancer are …

[HTML][HTML] Ovarian cancer development and metastasis

E Lengyel - The American journal of pathology, 2010 - Elsevier
The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors
because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only …

[HTML][HTML] Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment

E Schoutrop, L Moyano-Galceran, S Lheureux… - Seminars in cancer …, 2022 - Elsevier
Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Recent technological advances in using mouse models to study ovarian cancer

CD House, L Hernandez, CM Annunziata - Frontiers in oncology, 2014 - frontiersin.org
Serous epithelial ovarian cancer (SEOC) is the most lethal gynecological cancer in the
United States with disease recurrence being the major cause of morbidity and mortality …

Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

TL Yeung, CS Leung, KP Yip… - … of Physiology-Cell …, 2015 - journals.physiology.org
Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …