A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

A Maida, A Zota, KA Sjøberg… - The Journal of …, 2022 - Am Soc Clin Investig
Dietary protein intake is linked to an increased incidence of type 2 diabetes (T2D). Although
dietary protein dilution (DPD) can slow the progression of some aging-related disorders …

[HTML][HTML] Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction

CL Green, HH Pak, NE Richardson, V Flores, D Yu… - Cell metabolism, 2022 - cell.com
Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …

Long-term effects of dietary protein and branched-chain amino acids on metabolism and inflammation in mice

WC Mu, E VanHoosier, CM Elks, RW Grant - Nutrients, 2018 - mdpi.com
Aging is the main factor involved in the onset of degenerative diseases. Dietary protein
restriction has been shown to increase the lifespan of rodents and improve metabolic …

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

CM Hill, T Laeger, DC Albarado, DH McDougal… - Scientific reports, 2017 - nature.com
Dietary protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy
expenditure and food intake, and these effects require the metabolic hormone fibroblast …

Low protein diets produce divergent effects on energy balance

A Pezeshki, RC Zapata, A Singh, NJ Yee… - Scientific reports, 2016 - nature.com
Diets deficient in protein often increase food consumption, body weight and fat mass;
however, the underlying mechanisms remain poorly understood. We compared the effects of …

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

U Liisberg, LS Myrmel, E Fjære, AK Rønnevik… - Adipocyte, 2016 - Taylor & Francis
abstract The notion that the obesogenic potential of high fat diets in rodents is attenuated
when the protein: carbohydrate ratio is increased is largely based on studies using casein or …

[PDF][PDF] Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARa and FGF21 in mice with hepatic ablation of brain-derived …

S Teillon, GA Calderon, M Rios - J Endocrinol, 2010 - academia.edu
Brain-derived neurotropic factor (BDNF) mediates many aspects of neuronal function, and
plays a chief role in the central regulation of energy balance. In the periphery, it is expressed …

[HTML][HTML] Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine-and choline-deficient diet

N Tanaka, S Takahashi, Y Zhang, KW Krausz… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract Fibroblast growth factor 21 (FGF21) is a modulator of energy homeostasis and is
increased in human nonalcoholic liver disease (NAFLD) and after feeding of methionine …

[HTML][HTML] Clinical evidence and mechanisms of high-protein diet-induced weight loss

J Moon, G Koh - Journal of obesity & metabolic syndrome, 2020 - ncbi.nlm.nih.gov
Several clinical trials have found that consuming more protein than the recommended
dietary allowance not only reduces body weight (BW), but also enhances body composition …

The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention

S Oller Moreno, O Cominetti… - PROTEOMICS …, 2018 - Wiley Online Library
Purpose The nutritional intervention program “DiOGenes” focuses on how obesity can be
prevented and treated from a dietary perspective. We generated differential plasma …