Abstract Rationale Indirect-acting serotonin (5-HT) receptor agonists can enhance the
antinociceptive effects of morphine; however, the specific 5-HT receptor subtype (s) …

Abstract Serotonergic (5-HT) systems modulate pain, and drugs acting on 5-HT systems are
used with opioids to treat pain. This study examined the effects of 5-HT receptor agonists on …

The 5-HT 1A partial agonists, buspirone, ipsapirone and gepirone did not affect the latency
to respond in the tail flick test to heat. However, they strongly attenuated the antinooiceptive …

There has been increasing interest in the potential therapeutic effects of drugs with agonist
properties at serotonin 2A subtype (5-HT2A) receptors (eg, psychedelics), including …

Abstract Rationale The serotonin (5-HT) system is involved in pain modulation, and 5-HT
receptor agonists can enhance antinociceptive effects of mu opioid receptor agonists. Less …

Rationale: The dopamine (DA) D3/2 agonist 7-OH-DPAT attenuates the acute
antinociceptive, discriminative stimulus, locomotor activating, and reinforcing effects of mu …

Behavioural and pharmacological evidence indicates that non-opioid analgesia in defeated
male mice is initiated by anxiety and that serotongergic (5-HT) substrates are implicated. In …

In mice injected with formalin into the hindpaw, the 5-HT1A receptor agonists, 8-OH-DPAT
and flesinoxan, equipotently inhibited the early phase (EP) and late phase (LP) of licking. At …

Hydroxytryptamine (5-HT) receptor blockade by administration of mianserin (1 mg/kg) or
metergoline (0.25 mg/kg) shortened the response latencies of rats in the hot-plate (hind-paw …

Opioids are among the most effective analgesics and the mainstay of pain management.
However, concerns about safety and abuse liability have challenged their widespread use …