Critical to the clinical evaluation of effective novel therapies for lung cancer is the early and
accurate determination of tumor response, which requires an understanding of the sources …

Advances in molecular medicine offer the potential to move cancer therapy beyond
traditional cytotoxic treatments to safer and more effective targeted therapies based on …

RATIONALE: Early detection of tumor response to therapy is a key goal. Finding
measurement algorithms capable of early detection of tumor response could individualize …

Multimodality imaging measurements of treatment response are critical for clinical practice,
oncology trials, and the evaluation of new treatment modalities. The current standard for …

There are two key challenges hindering effective use of quantitative assessment of imaging
in cancer response assessment: 1) Radiologists usually describe the cancer lesions in …

OBJECTIVE: This study was designed to characterize the reproducibility of measurement for
tumor volumes and their longest tumor diameters (LDs) and estimate the potential impact of …

Tumor response assessment has been a foundation for advances in cancer therapy. Recent
discoveries of effective targeted therapy for specific genomic abnormalities in lung cancer …

Quantification of tumor burden and assessment of changes in tumor size after chemotherapy
are commonly performed to evaluate treatment response in oncology trials. Validation and …

In cancer-drug development, a number of different end points have been used to establish
efficacy and support regulatory approval, such as overall survival, progression-free survival …

Response evaluation by means of response rates using radiological imaging techniques is
well established and plays a pivotal role in the development of new anti-cancer agents. It is …