RNA sequencing and prediction tools for circular RNAs analysis

E López-Jiménez, AM Rojas, E Andrés-León - Circular RNAs: Biogenesis …, 2018 - Springer
Circular RNAs (circRNAs) are noncoding and single-stranded RNA transcripts able to form
covalently circular-closed structures. They are generated through alternative splicing events …

Computational strategies for exploring circular RNAs

Y Gao, F Zhao - Trends in Genetics, 2018 - cell.com
Recent studies have demonstrated that circular RNAs (circRNAs) are ubiquitous and have
diverse functions and mechanisms of biogenesis. In these studies, computational profiling of …

FUCHS—towards full circular RNA characterization using RNAseq

F Metge, LF Czaja-Hasse, R Reinhardt, C Dieterich - PeerJ, 2017 - peerj.com
Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge
during RNA maturation through a process called back-splicing. A downstream 5′ splice site …

Detecting circular RNAs: bioinformatic and experimental challenges

L Szabo, J Salzman - Nature Reviews Genetics, 2016 - nature.com
The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of
gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect …

Computational approaches for circular RNA analysis

T Jakobi, C Dieterich - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Circular RNAs (circRNAs) are a recent addition to the expanding universe of RNA species
and originate through back‐splicing events from linear primary transcripts. CircRNAs show …

Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers

L Bolha, M Ravnik-Glavač… - International journal of …, 2017 - Wiley Online Library
Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that form covalently
closed continuous loop structures, lacking the terminal 5′ and 3′ ends. CircRNAs are …

CIRI: an efficient and unbiased algorithm for de novo circular RNA identification

Y Gao, J Wang, F Zhao - Genome biology, 2015 - Springer
Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable
and ubiquitous noncoding RNA molecules in animals. Comprehensive detection of …

Advances in the identification of circular RNAs and research into circRNAs in human diseases

S Jiao, S Wu, S Huang, M Liu, B Gao - Frontiers in Genetics, 2021 - frontiersin.org
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs (ncRNAs) with a
closed-loop structure that are mainly produced by variable processing of precursor mRNAs …

Circular RNAs as promising biomarkers in cancer: detection, function, and beyond

S Li, L Han - Genome medicine, 2019 - Springer
Editorial summary Circular RNAs (circRNAs) are 3′–5′ covalently closed RNA rings
produced from back-splicing of precursor mRNA in eukaryotes. Recent studies, using both …

CirComPara: a multi-method comparative bioinformatics pipeline to detect and study circRNAs from RNA-seq data

E Gaffo, A Bonizzato, G Te Kronnie, S Bortoluzzi - Non-coding RNA, 2017 - mdpi.com
Circular RNAs (circRNAs) are generated by back-splicing of immature RNA forming
covalently closed loops of intron/exon RNA molecules. Pervasiveness, evolutionary …