Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in
animal models, in humans with congenital complete leptin deficiency, and observational and …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Leptin is the first of a group of adipocyte-secreted hormones to be used clinically to treat
hypoleptinemic states. In children with congenital leptin deficiency and extreme obesity …

This issue of the journal Metabolism celebrates the 20 years since the discovery of the
prototypical adipose tissue secreted hormone leptin [1],[2],[3],[4],[5],[6],[7],[8],[9]. Leptin has …

Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …

Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways …

Leptin is a pleiotropic cytokine‐like hormone that is involved in the regulation of energy
intake and expenditure, neuroendocrine function, immunity and lipid and glucose …

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and
metabolic functions. In this review, we describe the role of leptin in human physiology and …