Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …

Ribosome biogenesis is a fundamental process that is conserved in eukaryotes. Although
spectacular progress has been made in understanding mammalian ribosome synthesis in …

Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA
helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while …

The synthesis of ribosomal subunits in the nucleolus is a conserved, essential process that
results in cytoplasmic ribosomes with precisely processed and folded rRNAs assembled …

Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor
particles (pre-ribosomal particles) containing ribosomal RNA (rRNA) precursors, ribosomal …

During eukaryotic ribosome biogenesis, nascent ribosomal RNA (rRNA) forms pre-
ribosomal particles containing ribosomal proteins and assembly factors. Subsequently …

Previous work from our lab suggests that a group of interdependent assembly factors (A3
factors) is necessary to create early, stable preribosomes. Many of these proteins bind at or …

Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

Similar to proteins, RNA molecules must fold into the correct conformation and associate
with protein complexes in order to be functional within a cell. RNA helicases rearrange RNA …