FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

The fibroblast growth factor (FGF) receptor complex is a ubiquitous regulator of development
and adult tissue homeostasis that bridges the peri-cellular matrix and the intracellular …

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing
and adult organism. The accumulated wealth of structural information on the FGF signalling …

Polypeptides of the fibroblast growth factor (FGF) family are ubiquitous bioregulators within
tissues whose activity is controlled by heparan sulfates within the pericellular matrix. FGF …

Fibroblast growth factors (FGFs) are members of a protein family with a broad range of
biological activities. The best characterized FGFs interact with two distinct extracellular …

Fibroblast growth factors (FGFs) signal in a paracrine or endocrine fashion to mediate a
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …

Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and
heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with …

Fibroblast growth factors (FGFs) interact with heparan sulfate glycosaminoglycans and the
extracellular domains of FGF cell surface receptors (FGFRs) to trigger receptor activation …

The 22 members of the fibroblast growth factor (FGF) family have been implicated in cell
proliferation, differentiation, survival, and migration. They are required for both development …

To elucidate the structural determinants governing specificity in fibroblast growth factor
(FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed …