Aims: The lamina propria is inevitably involved in epithelial transformation. The aim was to
evaluate the dynamic cellular changes in the tumour lamina propria throughout the …

Aim: In colorectal carcinomas, cyclooxygenase‐2 (COX‐2) is expressed predominantly by
epithelial cells and is implicated in tumour progression. Tumour‐associated macrophages …

Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into
the bowel wall. Although assessment of serosal involvement is an important pathological …

In order to examine stromal–epithelial interaction during the oncogenic progression of large
bowel tumors, the association between pericryptal fibroblast sheath (PCFS) and expression …

Aims The role of tumour‐associated macrophages (TAM s) in colorectal cancer (CRC)
remains elusive. In this study, we aimed to examine the correlation between TAM s …

Recently, depressed adenomas (DA) of the colorectum have been frequently detected in
Japan. The natural history and carcinogenesis of these DA remain unclear. The histological …

Aims: To determine the pattern of macrophage infiltration in colon cancers and its correlation
with clinicopathological characteristics. Methods and results: Colon cancers from 100 …

Morphologically, early colorectal cancers are divided into two types: polypoid cancers and
non‐polypoid cancers. They vary in growth pattern, progression, and genetic alteration …

To analyze the cell kinetics of ulcerative colitis (UC)‐associated dysplasia, cyclin A, cyclin
D1, cyclin E, cdk2, cdk4, p21Waf1, and p27Kip1 were immunohistochemically examined, in …

Background: Little is known about the molecular biological features of large flat tumors or
laterally spreading tumors (LSTs) of the colon and rectum. Methods: The cyclooxygenase …