[HTML][HTML] Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation
P Bhargava, MD Smith, L Mische… - The Journal of …, 2020 - Am Soc Clin Investig
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are
cholesterol metabolites that can signal through receptors on cells throughout the body …
cholesterol metabolites that can signal through receptors on cells throughout the body …
[HTML][HTML] Bile acids and neurological disease
MJ Hurley, R Bates, J Macnaughtan… - Pharmacology & …, 2022 - Elsevier
This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …
diseases due to their central involvement with the gut-liver-brain axis and their physiological …
[HTML][HTML] Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
Background While Alzheimer disease (AD) and vascular dementia (VaD) may be
accelerated by hypercholesterolemia, the mechanisms underlying this association are …
accelerated by hypercholesterolemia, the mechanisms underlying this association are …
[HTML][HTML] Metabolomic profiling of bile acids in clinical and experimental samples of Alzheimer's disease
X Pan, CT Elliott, B McGuinness, P Passmore… - Metabolites, 2017 - mdpi.com
Certain endogenous bile acids have been proposed as potential therapies for ameliorating
Alzheimer's disease (AD) but their role, if any, in the pathophysiology of this disease is not …
Alzheimer's disease (AD) but their role, if any, in the pathophysiology of this disease is not …
[HTML][HTML] Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced …
The goal of this study was to identify the intrinsic links that explain the effect of a Western diet
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …
[HTML][HTML] Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—an emerging role for gut microbiome
Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …
TUDCA: An agonist of the bile acid receptor GPBAR1/TGR5 with anti‐inflammatory effects in microglial cells
N Yanguas‐Casás, MA Barreda‐Manso… - Journal of cellular …, 2017 - Wiley Online Library
Bile acids are steroid acids found in the bile of mammals. The bile acid conjugate
tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of stroke …
tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of stroke …
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers
K Nho, A Kueider-Paisley… - Alzheimer's & …, 2019 - Elsevier
Abstract Introduction Bile acids (BAs) are the end products of cholesterol metabolism
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …
Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis
RR Voskuhl, N Itoh, A Tassoni… - Proceedings of the …, 2019 - National Acad Sciences
Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the
brain during health, and regional differences in the transcriptome may occur for each cell …
brain during health, and regional differences in the transcriptome may occur for each cell …