Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are
cholesterol metabolites that can signal through receptors on cells throughout the body …

This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

Background While Alzheimer disease (AD) and vascular dementia (VaD) may be
accelerated by hypercholesterolemia, the mechanisms underlying this association are …

Certain endogenous bile acids have been proposed as potential therapies for ameliorating
Alzheimer's disease (AD) but their role, if any, in the pathophysiology of this disease is not …

The goal of this study was to identify the intrinsic links that explain the effect of a Western diet
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …

Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …

Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …

Bile acids are steroid acids found in the bile of mammals. The bile acid conjugate
tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of stroke …

Abstract Introduction Bile acids (BAs) are the end products of cholesterol metabolism
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …

Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the
brain during health, and regional differences in the transcriptome may occur for each cell …