Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen …

C Tu, H Lu, T Zhou, W Zhang, L Deng, W Cao, Z Yang… - Biomaterials, 2022 - Elsevier
The diabetic wound is easily to develop into a chronic wound because of the extremely
serious and complex inflammatory microenvironment including biofilm formation, over …

A Nanozyme‐Immobilized Hydrogel with Endogenous ROS‐Scavenging and Oxygen Generation Abilities for Significantly Promoting Oxidative Diabetic Wound …

Z Li, Y Zhao, H Huang, C Zhang, H Liu… - Advanced …, 2022 - Wiley Online Library
Non‐healing wound is a common complication of diabetic patients associated with high
morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in …

Injectable, antibacterial, ROS scavenging and pro-angiogenic hydrogel adhesives promote chronic wound healing in diabetes via synergistic release of NMN and …

Z Liang, J Luo, S Liu, Y Gu, Z Cui, Y Zhu, Z Yu… - Chemical Engineering …, 2023 - Elsevier
Diabetic wound care continues a significant clinical problem due to the complex wound
microenvironment characterized by excessive ROS, bacterial infection, persistent …

Biomimetic Nanozyme-Decorated Hydrogels with H2O2-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

Y Zhao, D Wang, T Qian, J Zhang, Z Li, Q Gong… - ACS …, 2023 - ACS Publications
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing

Y Pu, P Wang, R Yang, X Tan, T Shi, J Ma… - Journal of Materials …, 2022 - pubs.rsc.org
Chronic wounds, especially diabetic wounds, involve abnormally long inflammatory periods
due to their pathological microenvironment of high reactive oxygen species (ROS) levels …

Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria

S Wang, H Zheng, L Zhou, F Cheng, Z Liu, H Zhang… - Nano …, 2020 - ACS Publications
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

Z Xu, G Liu, L Zheng, J Wu - Nano Research, 2023 - Springer
High oxidative stress injury and bacterial infection are the main challenges that impair
wound healing in diabetic patients. Therefore, a hydrogel with enhanced antimicrobial and …

Glucose oxidase and Fe 3 O 4/TiO 2/Ag 3 PO 4 co-embedded biomimetic mineralization hydrogels as controllable ROS generators for accelerating diabetic wound …

T Huang, B Yuan, W Jiang, Y Ding, L Jiang… - Journal of Materials …, 2021 - pubs.rsc.org
The hyperglycemic environment and the presence of bacterial infections delay the healing of
diabetic wounds. Herein, glucose oxidase (GOx) and Fe3O4/TiO2/Ag3PO4 were embedded …

Nanohybrid double network hydrogels based on a platinum nanozyme composite for antimicrobial and diabetic wound healing

Z Zhou, X Mei, K Hu, M Ma, Y Zhang - ACS Applied Materials & …, 2023 - ACS Publications
Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory
response hinders diabetic wounds from healing. It leads to the accumulation of large …

ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds

H Zhao, J Huang, Y Li, X Lv, H Zhou, H Wang, Y Xu… - Biomaterials, 2020 - Elsevier
Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal
diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or …