[HTML][HTML] microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice
Small non-coding miRNA act as key regulators of several physiological processes due to
their ability to interact with numerous target mRNA within a network. Whilst several miRNA …
their ability to interact with numerous target mRNA within a network. Whilst several miRNA …
[HTML][HTML] MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response
A Iyer, E Zurolo, A Prabowo, K Fluiter, WGM Spliet… - 2012 - journals.plos.org
Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of
inflammation in human neurological disorders. In the present study we investigated the role …
inflammation in human neurological disorders. In the present study we investigated the role …
MicroRNAs mediating CNS inflammation: small regulators with powerful potential
MicroRNAs (miRNAs) are a family of small non-coding RNAs (∼ 22 nucleotides) that fine-
tune protein expression by either silencing mRNA translation or directly targeting gene …
tune protein expression by either silencing mRNA translation or directly targeting gene …
[HTML][HTML] MicroRNA-146a is a wide-reaching neuroinflammatory regulator and potential treatment target in neurological diseases
W Fan, C Liang, M Ou, T Zou, F Sun… - Frontiers in molecular …, 2020 - frontiersin.org
Progressive functional deterioration and loss of neurons underlies neurological diseases
and constitutes an important cause of disability and death worldwide. The causes of various …
and constitutes an important cause of disability and death worldwide. The causes of various …
Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models
YY Li, JG Cui, JM Hill, S Bhattacharjee, Y Zhao… - Neuroscience …, 2011 - Elsevier
A mouse and human brain-enriched micro-RNA-146a (miRNA-146a) is known to be
important in modulating the innate immune response and inflammatory signaling in certain …
important in modulating the innate immune response and inflammatory signaling in certain …
[HTML][HTML] Enhanced cognition and neurogenesis in miR-146b deficient mice
K Chithanathan, K Somelar, M Jürgenson… - Cells, 2022 - mdpi.com
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b, which
are both known to suppress a variety of immune responses. Here in this study, we show that …
are both known to suppress a variety of immune responses. Here in this study, we show that …
[HTML][HTML] Up-regulation of miRNA-146a in progressive, age-related inflammatory neurodegenerative disorders of the human CNS
The human brain-and retinal-resident microRNA-146a (miRNA-146a) is an inducible, NF-kB-
regulated small non-coding RNA (sncRNA) whose increased expression is associated with …
regulated small non-coding RNA (sncRNA) whose increased expression is associated with …
[HTML][HTML] MiR-155: an important regulator of neuroinflammation
VD Zingale, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …
at the post-transcriptional level and that play an important role in many cellular processes …
[HTML][HTML] MicroRNAs in neuroinflammation: implications in disease pathogenesis, biomarker discovery and therapeutic applications
JA Slota, SA Booth - Non-coding RNA, 2019 - mdpi.com
The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …
response. Under normal circumstances this response is tightly controlled, however …
[HTML][HTML] Paradoxical attenuation of neuroinflammatory response upon LPS challenge in miR-146b deficient mice
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-
146a/b), both of which are known to suppress immune responses in a variety of conditions …
146a/b), both of which are known to suppress immune responses in a variety of conditions …