The widespread application of antiandrogen therapies has aroused a significant increase in
the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here …

Despite the great advances in target therapy, lung cancer remains the top cause of cancer-
related death worldwide. G protein-coupled receptor neurokinin-1 (NK1R) is shown to play …

Prostate cancer (PC), which has high morbidity and mortality among elderly men, is
becoming the most common malignancy in men. The progression of PC is associated with …

Prostate cancer (PC) is the second leading cause of cancer death in men in Western society.
Current therapies for PC remain, however, unsatisfactory and PC frequently progresses …

Inflammation of the prostate is a risk factor for the development of prostate cancer. In the
aging prostate, regions of inflammatory atrophy are foci for prostate epithelial cell …

Although it is known that inflammation plays a critical role in prostate tumorigenesis, the
underlying processes are not well understood. Based on analysis of genetically engineered …

Simple Summary Pancreatic ductal adenocarcinoma is the most common form of pancreatic
cancer. It is known for low life expectancies after diagnosis and very limited treatment …

BACKGROUND The androgen‐regulated homeodomain transcription factor NKX3. 1 plays
roles in early prostate development and functions as a prostate‐specific tumor suppressor …

Background Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate
cancer (PCa) that has become a major challenge in clinics. Understanding the …

Diminished expression of NKX3. 1 is associated with prostate cancer progression in
humans, and in mice, loss of nkx3. 1 leads to epithelial cell proliferation and altered gene …