MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Iron is essential for normal cellular functioning of the central nervous system. Abnormalities
in iron metabolism may lead to neuronal death and abnormal iron deposition in the brain …

Inflammatory destruction of iron-rich myelin is characteristic of multiple sclerosis (MS).
Although iron is needed for oligodendrocytes to produce myelin during development, its …

J. Neurochem.(2012) 120, 7–25. Abstract Iron, an essential element used for a multitude of
biochemical reactions, abnormally accumulates in the CNS of patients with multiple …

Iron is an essential element involved in a multitude of bodily processes. It is tightly regulated,
as elevated deposition in tissues is associated with diseases such as multiple sclerosis …

Objective Iron may contribute to the pathogenesis and progression of multiple sclerosis (MS)
due to its accumulation in the human brain with age. Our study focused on nonheme iron …

Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients
have abnormal deposition of iron in both gray and white matter structures. Data is emerging …

Increased brain iron concentration is often reported concurrently with disease development
in multiple sclerosis (MS) and other neurodegenerative diseases. However, it is unclear …

Increased iron deposition might be implicated in multiple sclerosis (MS). Recent
development of MRI enabled to determine brain iron levels in a quantitative manner, which …

Recent advances in susceptibility MRI have dramatically improved the visualization of deep
gray matter brain regions and the quantification of their magnetic properties in vivo …