Chronic stress is linked to development of depression and may trigger neurobiological
changes underlying the disease. Downregulation of the secretory peptide brain-derived …

Chronic unpredictable stress (CUS) is a widely used animal model of depression. The
present study was undertaken to investigate behavioral, physiological and molecular effects …

Despite growing evidences of an association between brain-derived neurotrophic factor
(BDNF) and antidepressant effects, the neurotrophic hypothesis of depression is challenged …

Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the
hippocampal damage observed in depression. BDNF has a complex gene structure with …

The gene coding for the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is a stress-
responsive gene. Changes in its expression may underlie some of the pathological effects of …

Chronic stress is a trigger for several psychiatric disorders, including depression; however,
critical individual differences in resilience to both the behavioral and the neurochemical …

Chronic stress is a major risk factor for the development of depression. Brain-derived
neurotrophic factor (BDNF) plays an important role in neural functions and exhibits …

Chronic exposure to stressful environment is a key risk factor contributing to the
development of depression. However, the mechanisms involved in this process are still …

Stress activates the hypothalamo–pituitary–adrenal (HPA) axis, regulates the expression of
brain-derived neurotrophic factor (BDNF) in the brain, and mediates mood. Antidepressants …

Exposure of an organism to chronic psychosocial stress may affect brain-derived
neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric …