Imidazo [2, 1-b][1, 3, 4] thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells

S Cascioferro, GL Petri, B Parrino, D Carbone… - European journal of …, 2020 - Elsevier
A new series of eighteen imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives was efficiently
synthesized and screened for antiproliferative activity against the National Cancer Institute …

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

S Cascioferro, G Li Petri, B Parrino, B El Hassouni… - Molecules, 2020 - mdpi.com
A new series of imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives was efficiently synthesized
and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal …

2, 6-Disubstituted imidazo [2, 1-b][1, 3, 4] thiadiazoles: Search for anticancer agents

MN Noolvi, HM Patel, S Kamboj, A Kaur… - European journal of …, 2012 - Elsevier
In this study, some novel 2, 6-disubstituted imidazo [2, 1-b][1, 3, 4] thiadiazoles 4 (a–i), 7 (a–
p) and 11 (a–i) were synthesized from 5-substituted-1, 3, 4-thiadiazol-2-amine. The newly …

Biological evaluation of the antiproliferative and anti-migratory activity of a series of 3-(6-phenylimidazo [2, 1-b][1, 3, 4] thiadiazol-2-yl)-1H-indole derivatives against …

GL Petri, S Cascioferro, B El Hassouni… - Anticancer …, 2019 - ar.iiarjournals.org
Heterocyclic rings are recognized as key components of many natural, semi-synthetic and
synthetic molecules with a broad spectrum of biological activities. Among these molecules …

Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo [2, 1-b] thiazoles

S Koppireddi, DRK Chilaka, S Avula… - Bioorganic & Medicinal …, 2014 - Elsevier
Abstract A series of new 3, 6-diphenylimidazo [2, 1-b] thiazole derivatives (4a–l) are
synthesized and evaluated for their anticancer activity. Some of the synthesized compounds …

New imidazo [1, 2-b] pyrazoles as anticancer agents: synthesis, biological evaluation and structure activity relationship analysis

S Grosse, V Mathieu, C Pillard, S Massip… - European journal of …, 2014 - Elsevier
Synthesis and functionalization strategies of the imidazo [1, 2-b] pyrazole core were
developed giving a rapid access to three series of novel imidazo [1, 2-b] pyrazole type …

Evaluation of imidazo [2, 1–b] thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects

RM Sbenati, MH Semreen, AM Semreen… - Bioorganic & Medicinal …, 2021 - Elsevier
Several reports have highlighted imidazo [2, 1-b] thiazole derivatives as potential
antiproliferative agents. They act through kinase inhibition, tubulin inhibition, and other …

Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents

SS Karki, K Panjamurthy, S Kumar, M Nambiar… - European journal of …, 2011 - Elsevier
Levamisole, the imidazo [2, 1-b] thiazole derivative has been reported as a potential
antitumor agent. In the present study, we synthesized, characterized and evaluated …

Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo [2, 1-b] thiazole derivatives bearing pyrazole moieties

AR Ali, ER El-Bendary, MA Ghaly, IA Shehata - European journal of …, 2014 - Elsevier
Abstract A series of imidazo [2, 1-b] thiazoles bearing pyrazole moieties 4–6 (a–c) was
synthesized through the reaction of 6-hydrazinylimidazo [2, 1-b] thiazoles 3a–c with different …

New imidazo [2, 1-b] thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies

JH Park, MI El-Gamal, YS Lee, CH Oh - European journal of medicinal …, 2011 - Elsevier
A series of 18 new imidazo [2, 1-b] thiazole derivatives was synthesized. Their in vitro
antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line …