In vivo Role of Cytochrome P450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans

O Doroshyenko, U Fuhr, D Kunz, D Frank… - … Biomarkers & Prevention, 2009 - AACR
Acrylamide, a potential food carcinogen in humans, is biotransformed to the epoxide
glycidamide in vivo. Both acrylamide and glycidamide are conjugated with glutathione …

Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity

U Fuhr, MI Boettcher, M Kinzig-Schippers… - … Biomarkers & Prevention, 2006 - AACR
High amounts of acrylamide in some foods result in an estimated daily mean intake of 50 μg
for a western style diet. Animal studies have shown the carcinogenicity of acrylamide upon …

Human CYP2E1 mediates the formation of glycidamide from acrylamide

E Settels, U Bernauer, R Palavinskas, HS Klaffke… - Archives of …, 2008 - Springer
Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to
what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared …

Expression profile of human cells in culture exposed to glycidamide, a reactive metabolite of the heat-induced food carcinogen acrylamide

FC Clement, R Dip, H Naegeli - Toxicology, 2007 - Elsevier
Recent findings of acrylamide in many common foods have sparked renewed interest in
assessing human health hazards and the long-term risk associated with exposure to vinyl …

Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems

N Koyama, M Yasui, Y Oda, S Suzuki… - Environmental and …, 2011 - Wiley Online Library
The recent finding that acrylamide (AA), a genotoxic rodent carcinogen, is formed during the
frying or baking of a variety of foods raises human health concerns. AA is known to be …

Curcumin and (−)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells

X Shan, Y Li, X Meng, P Wang, P Jiang… - Food and Chemical …, 2014 - Elsevier
Acrylamide, a proven rodent carcinogen, is present in carbohydrate-rich food heated at high
temperatures. It can be metabolized into glycidamide mainly by cytochrome P450 2E1 …

Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes

N Duale, T Bjellaas, J Alexander, G Becher… - Toxicological …, 2009 - academic.oup.com
Acrylamide (AA) is formed in heat treated carbohydrate rich foods in the so-called Maillard
reaction. AA is readily absorbed in the body and converted to glycidamide (GA) by …

The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide

D Taubert, R Glöckner, D Müller, E Schömig - Toxicology letters, 2006 - Elsevier
Genotoxic effects of acrylamide are supposed to result from oxidative biotransformation to
glycidamide. After incubation of rat liver slices with acrylamide we detected free glycidamide …

Scientific opinion on acrylamide in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2015 - Wiley Online Library
EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has
widespread uses as an industrial chemical. It is also formed when certain foods are …

Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts

BI Ghanayem, LP McDaniel, MI Churchwell… - Toxicological …, 2005 - academic.oup.com
Acrylamide (AA) is an animal carcinogen, neurotoxin, and reproductive toxin. AA is formed in
baked and fried carbohydrate-rich foods. Metabolism of AA occurs via epoxidation to …