This work aimed at obtaining an optimized itraconazole (ITZ) solid oral formulation in terms
of palatability and dissolution rate by combining different polymers using hot melt extrusion …

Abstract Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate
copolymer dispersion) which is used for taste masking and moisture protection, has shown …

The purpose of this work was to increase the solubility and the dissolution rate of
itraconazole, which was chosen as the model drug, by obtaining an amorphous solid …

Solid dispersions containing different ratios of itraconazole and
hydroxypropylmethylcellulose (HPMC) were prepared by solvent casting. Based on dose …

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug
products for the first time. For this, a combined mixture design was employed using …

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus®(polyethylene glycol,
polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were …

Abstract Formulation of poorly water-soluble drugs is a significant challenge in the
development of oral solid dosage forms. The objective was to investigate the effect of hot …

The objective of this study was to formulate aripiprazole (ARI)-loaded pH-modulated solid
dispersions (SD) to enhance solubility, dissolution, and bioavailability via hot-melt extrusion …

The aim of this study was to investigate the efficiency of hydrophilic polymers to enhance the
dissolution rate of poorly water-soluble active pharmaceutical ingredients (APIs) processed …

The objective of this study was to develop solid solution (SSL) using hot-melt extrusion as a
continuous manufacturing method. Powder blends of artesunate (ARS) a water insoluble …