Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker
in MS, the most common demyelinating disease of the CNS. We have attempted to identify …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

Oligoclonal IgM bands (OCMB) against myelin lipids predict an aggressive multiple sclerosis
(MS) course. However, the clinical significance of OCMB without lipid specificity, present in …

Intrathecal IgM synthesis was assessed through the detection of oligoclonal bands in
cerebrospinal fluid (CSF) and through calculation of IgM index values and total CSF IgM …

BACKGROUND: Recent findings support the important role of antibodies in multiple
sclerosis (MS) physiopathology. Thus, local IgG synthesis is a hallmark of the disease, and …

Background and Objective The presence of lipid-specific immunoglobulin M bands in the
cerebrospinal fluid (CSF) predicts an aggressive course in patients with relapsing–remitting …

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to
establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma …

Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a
central humoral response. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent …

The intrathecal synthesis of IgM in patients presenting with acute monosymptomatic
syndromes may be relevant in predicting eventual progression to multiple sclerosis but has …

Background: The authors have recently described that intrathecal IgM synthesis (ITMS)
correlates with a higher disability in patients with clinically definite MS (CDMS). Objective: To …