Prediction of local exposure following inhalation of a locally acting pulmonary drug is central
to the successful development of novel inhaled medicines, as well as generic equivalents …

In order to answer the question “what research remains to be done?” we review the current
state of the art in pharmaceutical aerosol deposition modeling and explore possible in vivo …

During the last decades, the importance of modeling and simulation in clinical drug
development, with the goal to qualitatively and quantitatively assess and understand …

Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

To accurately assess the potential therapeutic effects of airborne drugs, the deposition sites
of inhaled particles must be known. Herein, an original theory is presented for …

The portfolio of compounds approved for inhalation therapy has expanded rapidly for
treatment of lung diseases. To assess the efficacy and safety of inhaled medicines, a better …

Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …

Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires
extrapolation of experimental data sets from animal studies to humans. As the respiratory …

Pulmonary delivery for both locally and systemically acting drugs provides not only a
potentially convenient route but also a challenging area to pharmaceutical research. Drug …

Pulmonary drug disposition after inhalation is complex involving mechanisms, such as
regional drug deposition, dissolution, and mucociliary clearance. This study aimed to …